A simple, accurate, sensitive, precise and economical spectroscopic method has been developed and validated for the determination of asenapine maleate in bulk and tablet dosage formulation. The solvent used was double distilled water and methanol (for solubility purpose) to determine the asenapine maleate in bulk and tablet dosage formulation. The wavelength corresponding to maximum absorbance of the asenapine maleate was found at 268.60. The method obeys Beer’s law in the concentration range of 40-200 µg/ml and exhibited good correlation coefficient (R2=0.9994) and the regression of the curve was found y=0.0041x-0.0052 with excellent mean recovery (100.7-103.5 %). The limit of detection (LOD) and limit of quantitation (LOQ) were found to be 0.054 µg/ml and 0.163 µg/ml respectively. The method was validated for several parameters like accuracy, precision as per ICH guidelines. The values of relative standard deviation and percentage recovery were found to be satisfactory; indicating that the proposed method is precise, accurate and economical hence can be used for the routine analysis.
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